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The achievement of deep responses with modern therapy led the International Myeloma Working Group (IMWG) to propose new guidelines that included definitions of negative minimal residual disease (MRD) for standard response criteria. tutorial login android studio 7 Indeed, recent studies have reported nearly 50% MRD − rates, 5,8,9 and, more importantly, the prognostic value of MRD criteria was validated in clinical trials . tg gold login